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solid-phase synthesis of phosphorothioate oligonucleotides  (Biogen Inc)

 
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    Structured Review

    Biogen Inc solid-phase synthesis of phosphorothioate oligonucleotides
    Solid Phase Synthesis Of Phosphorothioate Oligonucleotides, supplied by Biogen Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/solid-phase+synthesis+of+phosphorothioate+oligonucleotides/solid+phase+synthesis+of+phosphorothioate+oligonucleotides/pm30179468-24-4-42
    Average 90 stars, based on 1 article reviews
    solid-phase synthesis of phosphorothioate oligonucleotides - by Bioz Stars, 2026-09
    90/100 stars

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    In Situ:

    Article Title: Solid-Phase Synthesis of Phosphorothioate Oligonucleotides Using Sulfurization Byproducts for in Situ Capping.
    Article Snippet: Oligonucleotides containing phosphorothioate (PS) linkages have recently demonstrated significant clinical utility.. PS oligonucleotides are manufactured via a solid-phase chain elongation process in which a four-reaction cycle consisting of detritylation, coupling, sulfurization, and failure sequence capping with Ac2O is repeated.. In the capping step uncoupled sequences are acetylated at the 5′-OH to stop the chain growth and control the levels of deletion, or (n-1), impurities.



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    Biogen Inc solid-phase synthesis of phosphorothioate oligonucleotides
    Solid Phase Synthesis Of Phosphorothioate Oligonucleotides, supplied by Biogen Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/solid-phase+synthesis+of+phosphorothioate+oligonucleotides/solid+phase+synthesis+of+phosphorothioate+oligonucleotides/pm30179468-24-4-42
    Average 90 stars, based on 1 article reviews
    solid-phase synthesis of phosphorothioate oligonucleotides - by Bioz Stars, 2026-09
    90/100 stars
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